How the growth rate of host cells affects cancer risk in a deterministic way How the growth rate of host cells affects cancer risk in a deterministic way - Archive ouverte HAL Access content directly
Journal Articles Chaos: An Interdisciplinary Journal of Nonlinear Science Year : 2017

How the growth rate of host cells affects cancer risk in a deterministic way How the growth rate of host cells affects cancer risk in a deterministic way

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Abstract

It is well known that cancers are significantly more often encountered in some tissues than in other ones. In this paper, by using a deterministic model describing the interactions between host, effector immune and tumor cells at the tissue level, we show that this can be explained by the dependency of tumor growth on parameter values characterizing the type as well as the state of the tissue considered due to the " way of life " (environmental factors, food consumption, drinking or smoking habits, etc.). Our approach is purely deterministic and, consequently, the strong correlation (r ¼ 0.99) between the number of detectable growing tumors and the growth rate of cells from the nesting tissue can be explained without evoking random mutation arising during DNA replications in nonmalignant cells or " bad luck ". Strategies to limit the mortality induced by cancer could therefore be well based on improving the way of life, that is, by better preserving the tissue where mutant cells randomly arise. Published by AIP Publishing. [http://dx. Cancer is clearly a disease triggered by initial mutations arising randomly during cell divisions, but these initial mutated cells become a tumor (a colony) only when the environment (the body to the largest extent) is no longer able to provide sufficiently strong barriers against that proliferation. If there is no doubt that the faster organ's stem cells replicate, the larger the risk of cancer in that organ, it is not yet clear whether these cancers are only due to random mutations in a fully genetically oriented approach (therefore to " bad luck ") or if they result from deterministic processes whose mechanisms involve the way of life (food consumption, drinking, smoking, lack of exercise…) and external factors such as air pollutants, for instance. Using a cancer model taking into account the interactions between the tumor cells and the healthy cells of the tumor micro-environment, we investigate whether cancer randomness is only apparent or could be explained by the causality with the quality of the surrounding tissue, a quality which would strongly depend on the way of life.
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Dates and versions

hal-01672074 , version 1 (23-12-2017)

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  • HAL Id : hal-01672074 , version 1

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Clement Draghi, Louise Viger, Fabrice Denis, Christophe Letellier. How the growth rate of host cells affects cancer risk in a deterministic way How the growth rate of host cells affects cancer risk in a deterministic way. Chaos: An Interdisciplinary Journal of Nonlinear Science, 2017, 27, pp.93101 - 93101. ⟨hal-01672074⟩
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