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Journal Articles Chaos, Solitons & Fractals Year : 2017

A chemotherapy combined with an anti-angiogenic drug applied to a cancer model including angiogenesis

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Abstract

Combined therapy made of a chemotherapy and antiangiogenic agents is a clinical treatment recommended for its efficiency. Since the optimization of a treatment against cancer relasp is still mostly based on oncologist's know-how, it is desirable to develop different approaches for such a task. Mathematical modelling is one of the promising ways. We here investigated the action of a combined therapy inserted to a mathematical cancer model in order to determine how the dynamics underlying tumor growth is governed by some key parameters. We here retained a chemotherapy (for instance, paclitaxel and carbo-platin) combined with an antiangiogenic drug (as bevacizumab) applied to a cancer model describing the interactions between host, immune, tumor and endothelial cells. The effects of such a therapy are investigated and the relevant role played by the " normal " tissue of the tumor micro-environment is evidenced.
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Dates and versions

hal-01672070 , version 1 (13-03-2018)

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Christophe Letellier, Sourav Kumar Sasmal, Clement Draghi, Fabrice Denis, Dibakar Ghosh. A chemotherapy combined with an anti-angiogenic drug applied to a cancer model including angiogenesis. Chaos, Solitons & Fractals, 2017, 99, pp.297 - 311. ⟨10.1016/j.chaos.2017.04.013⟩. ⟨hal-01672070⟩
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