Skip to Main content Skip to Navigation
Journal articles

A chemotherapy combined with an anti-angiogenic drug applied to a cancer model including angiogenesis

Abstract : Combined therapy made of a chemotherapy and antiangiogenic agents is a clinical treatment recommended for its efficiency. Since the optimization of a treatment against cancer relasp is still mostly based on oncologist's know-how, it is desirable to develop different approaches for such a task. Mathematical modelling is one of the promising ways. We here investigated the action of a combined therapy inserted to a mathematical cancer model in order to determine how the dynamics underlying tumor growth is governed by some key parameters. We here retained a chemotherapy (for instance, paclitaxel and carbo-platin) combined with an antiangiogenic drug (as bevacizumab) applied to a cancer model describing the interactions between host, immune, tumor and endothelial cells. The effects of such a therapy are investigated and the relevant role played by the " normal " tissue of the tumor micro-environment is evidenced.
Document type :
Journal articles
Complete list of metadatas

Cited literature [69 references]  Display  Hide  Download

https://hal-normandie-univ.archives-ouvertes.fr/hal-01672070
Contributor : Christophe Letellier <>
Submitted on : Tuesday, March 13, 2018 - 9:40:39 AM
Last modification on : Thursday, February 7, 2019 - 5:46:20 PM

Identifiers

Citation

Christophe Letellier, Sourav Kumar Sasmal, Clement Draghi, Fabrice Denis, Dibakar Ghosh. A chemotherapy combined with an anti-angiogenic drug applied to a cancer model including angiogenesis. Chaos, Solitons and Fractals, Elsevier, 2017, 99, pp.297 - 311. ⟨10.1016/j.chaos.2017.04.013⟩. ⟨hal-01672070⟩

Share

Metrics

Record views

203