Skip to Main content Skip to Navigation
Journal articles

Chronic Perigestational Exposure to Chlorpyrifos Induces Perturbations in Gut Bacteria and Glucose and Lipid Markers in Female Rats and Their Offspring

Abstract : An increasing burden of evidence is pointing toward pesticides as risk factors for chronic disorders such as obesity and type 2 diabetes, leading to metabolic syndrome. Our objective was to assess the impact of chlorpyrifos (CPF) on metabolic and bacteriologic markers. Female rats were exposed before and during gestation and during lactation to CPF (1 mg/kg/day). Outcomes such as weight, glucose and lipid profiles, as well as disturbances in selected gut bacterial levels, were measured in both the dams (at the end of the lactation period) and in their female offspring at early adulthood (60 days of age). The results show that the weight of CPF dams were lower compared to the other groups, accompanied by an imbalance in blood glucose and lipid markers, and selected gut bacteria. Intra-uterine growth retardation, as well as metabolic disturbances and perturbation of selected gut bacteria, were also observed in their offspring, indicating both a direct effect on the dams and an indirect effect of CPF on the female offspring. Co-treatment with inulin (a prebiotic) prevented some of the outcomes of the pesticide. Further investigations could help better understand if those perturbations mimic or potentiate nutritional risk factors for metabolic syndrome through high fat diet.
Document type :
Journal articles
Complete list of metadata

https://hal-u-picardie.archives-ouvertes.fr/hal-03641409
Contributor : Louise DESSAIVRE Connect in order to contact the contributor
Submitted on : Tuesday, May 3, 2022 - 10:59:28 AM
Last modification on : Tuesday, May 3, 2022 - 11:13:34 AM

File

toxics-10-00138-v2.pdf
Publisher files allowed on an open archive

Identifiers

Citation

Narimane Djekkoun, Flore Depeint, Marion Guibourdenche, Hiba El Khayat El Sabbouri, Aurélie Corona, et al.. Chronic Perigestational Exposure to Chlorpyrifos Induces Perturbations in Gut Bacteria and Glucose and Lipid Markers in Female Rats and Their Offspring. Toxics, MDPI, 2022, 10 (3), pp.138. ⟨10.3390/toxics10030138⟩. ⟨hal-03641409⟩

Share

Metrics

Record views

24

Files downloads

5