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Theses

Troubles cognitifs en oncologie : population à risque, impact, évolution sous traitement anticancéreux et prise en charge

Abstract : Cancer-related cognitive impairment is frequently reported by patients and can have an impact on quality of life, but also autonomy and adherence. Elderly patients appear to be particularly at risk for cognitive decline. Although the management of cognitive impairment is beginning to develop, there are no validated recommendations. The objective of this thesis was to focus on this thematic of cognition in oncology among three studies. The first study found an association between cognitive performance (working memory, digit memory and short-term memory) at the initiation of oral cancer treatment and adherence. The second study, conducted among elderly patients (≥ 70 years) treated with chemotherapy has demonstrated a cognitive impairment for 20 % of them. Pre-existing cognitive impairment and malnutrition were predictive factors for cognitive decline. Finally, the last work was a randomized controlled study evaluating the impact of computerized cognitive stimulation in patients treated with chemotherapy expressing a cognitive complaint. Cognitive stimulation demonstrated a benefit on cognitive complaint and working memory, and was also associated with a better quality of life and a lower level of depression.
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Submitted on : Tuesday, January 4, 2022 - 9:02:10 AM
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  • HAL Id : tel-03509188, version 1

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Mélanie dos Santos. Troubles cognitifs en oncologie : population à risque, impact, évolution sous traitement anticancéreux et prise en charge. Médecine humaine et pathologie. Normandie Université, 2021. Français. ⟨NNT : 2021NORMC420⟩. ⟨tel-03509188⟩

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