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Hydrogels adaptatifs stimuli-sensibles (temperature et lumière) à base d'acide hyaluronique (HA)

Abstract : Hydrogels are soft materials made of a cross-linked hydrophilic polymer able to swell and to absorb a large amount of water. They are particularly applied in the biomedical field, which requires the use of biocompatible materials. Hyaluronic acid (HA), a glycosaminoglycan from the extracellular matrix, is a promising choice because of its biocompatibility and its numerous functional groups, which allow its cross-linking in order to obtain a hydrogel. This manuscript will therefore deal with its functionalization with stimuli-responsive moieties to achieve physical hydrogels by modifying its physico-chemical environment. Firstly, thermo-responsive hydrogels will be obtained by grafting polymers displaying a LCST onto hyaluronic acid. It will be realised first with a commercial polyetheramine, Jeffamine® M2005, which resulted in derivatives able to undergo a transition towards a hydrogel by raising the temperature, as evidenced by rheological measurements. However, the transitions were taking place above 37 °C. Therefore, the grafting of a Poly(2-isopropyl-2-oxazoline)-co-Poly(2-n-butyl-2-oxazoline) synthesized in the lab was attempted through a one-pot reaction scheme. The tuning of the monomeric composition of the graft allowed a much better control of the hydrogel’s thermo-responsiveness, with transitions below 37 °C becoming achievable. Finally, a photo-responsive azobenzene moiety was also grafted on hyaluronic acid. Azobenzenes are able to shift from trans to cis conformation through exposure to UV-visible light of specific wavelengths. Their selective inclusion within α-cyclodextrin (α-CD), only possible with the trans conformation, will be evaluated as well as the possibility to design photo-responsive hydrogels by mixing HA-azobenzene with HA functionalized with α-CD.
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Submitted on : Friday, January 7, 2022 - 9:59:12 AM
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  • HAL Id : tel-03516216, version 1

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Mathieu Madau. Hydrogels adaptatifs stimuli-sensibles (temperature et lumière) à base d'acide hyaluronique (HA). Chimie organique. Normandie Université, 2021. Français. ⟨NNT : 2021NORMR066⟩. ⟨tel-03516216⟩

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