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Journal Articles Chemical Senses Year : 2021

Recovery From COVID-19-Related Olfactory Disorders and Quality of Life: Insights From an Observational Online Study

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Abstract

Although olfactory disorders (OD) are among the most significant symptoms of COVID-19, recovery time from COVID-19-related OD and their consequences on the quality of life remain poorly documented. We investigated the characteristics and behavioral consequences of COVID-19-related OD using a large-scale study involving 3111 French respondents (78% women) to an online questionnaire over a period of 9 months covering different epidemic waves (from 8 April 2020 to 13 January 2021). In the patients who subjectively recovered from COVID-19-related OD (N = 609), recovery occurred on average after 16 days and most of the time within 1 month (“normal” recovery range); 49 subjectively recovered in 1–2.5 months, and several cases took up to 6.5 months. Among the patients with ongoing OD (N = 2502), 974 were outside the “normal” recovery range (persistent OD) and reported OD for 1–10 months. Developing a persistent OD was more likely with increasing age and in women and was more often associated with parosmia and phantosmia. The deleterious impact of COVID-19-related OD on the quality of life was significantly aggravated by OD duration and was more pronounced in women. Because persistent OD is not infrequent after COVID-19, has deleterious consequences on the quality of life, and receives few solutions from the health practitioners, it would be beneficial to implement screening and treatment programs to minimize the long-term behavioral consequences of COVID-19-related OD.
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Ferdenzi-et-al_SuppMat_FinalClean.pdf (954.8 Ko) Télécharger le fichier
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Figure 1_Distribution of OD duration_comp.tif (222.34 Ko) Télécharger le fichier
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Figure 2_Effects on OD duration_comp.tif (104.77 Ko) Télécharger le fichier
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Figure 3_OR and Effects on persistence of OD_comp.tif (563.09 Ko) Télécharger le fichier
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Figure 4_Parosmia phantosmia_comp.tif (225.5 Ko) Télécharger le fichier
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Figure 5_Effects on total impact on QoL_comp.tif (484.1 Ko) Télécharger le fichier
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Dates and versions

hal-03432416 , version 1 (01-09-2022)

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Camille Ferdenzi, Christophe Bousquet, Pierre-Emmanuel Aguera, Morgane Dantec, Christelle Daudé, et al.. Recovery From COVID-19-Related Olfactory Disorders and Quality of Life: Insights From an Observational Online Study. Chemical Senses, 2021, 46, pp.bjab028. ⟨10.1093/chemse/bjab028⟩. ⟨hal-03432416⟩
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