DNA methylation and histone post-translational modifications in the mouse germline following in-vitro maturation of fresh or cryopreserved prepubertal testicular tissue

A. Oblette (1) , J. Rondeaux (1) , L. Dumont (1, 2) , M. Delessard (1) , J. Saulnier (1) , A. Rives (1, 2) , N. Rives (1, 2) , C. Rondanino (1)

1 GQG - Gamétogenèse et Qualité du Gamète - ULR 4308
2 CHU Rouen

The impact of sperm DNA damage on intracytoplasmic sperm injection (ICSI) outcomes remains controversial. The purpose of the study was to evaluate the prognostic value of several types of sperm nuclear damage on ICSI clinical pregnancy.

Mots clés: Sperm aneuploidy; ICSI outcomes; Sperm condensation; MSOME; Sperm DNA fragmentation

Domaines: Biologie de la reproduction

A. Oblette, J. Rondeaux, L. Dumont, M. Delessard, J. Saulnier, et al.. DNA methylation and histone post-translational modifications in the mouse germline following in-vitro maturation of fresh or cryopreserved prepubertal testicular tissue. 2019, 39 (3), pp.383-401. ⟨10.1016/j.rbmo.2019.05.007⟩. ⟨hal-02301873⟩