Editorial: Kidney and Distant Organ Crosstalk in Health and Disease

Natalia López-Andrés (1) , Frederic Jaisser (2, 3) , Jonatan Barrera-Chimal (4, 5)

1 Hospital Universitario Miguel Servet
2 CRC (UMR_S_1138 / U1138) - Centre de Recherche des Cordeliers
3 Intégrité du génome, ARN et cancer
4 UNAM - Universidad Nacional Autónoma de México = National Autonomous University of Mexico
5 Instituto Nacional de Cardiología Ignacio Chávez

Kidney disease is a health condition affecting a high number of patients with an estimated worldwide prevalence of 10% (Jager et al., 2019). Kidney dysfunction and the resulting accumulation of uremic toxins and chronic inflammation contribute to secondary injury in organs like the heart, vessels, lungs, gut, brain, liver, among others (Malek, 2018; Shang et al., 2020; Ambruso et al., 2021; Lai et al., 2021). On the other hand, kidney disease might be the result of co-morbidities or due to a primary insult in another organ (Ronco et al., 2018). The mechanisms by which this kidney-distant organ communication occurs remain partially understood. This Research Topic compiled original investigation and review papers that explored the connection between the kidneys and other organs/co-morbidities and result in the proposal of novel biomarkers, therapeutic strategies and bring new insights into the molecular mechanisms linking kidney disease with other organs. therapeutic strategies and bring new insights into the molecular mechanisms linking kidney disease with other organs

Mots clés: cardiorenal; kidney disease; hemodialysis; inflammation; fibrosis

Domaines: Urologie et Néphrologie

Natalia López-Andrés, Frederic Jaisser, Jonatan Barrera-Chimal. Editorial: Kidney and Distant Organ Crosstalk in Health and Disease. Frontiers in Physiology, 2021, 12, pp.712535. ⟨10.3389/fphys.2021.712535⟩. ⟨hal-03292750⟩