The IBD-disk is a reliable tool to assess the daily-life burden of patients with inflammatory bowel disease

Sara Tadbiri (1) , Maria Nachury (2, 3) , Yoram Bouhnik (4) , Mélanie Serrero (5) , Xavier Hebuterne (6) , Xavier Roblin (7) , Julien Kirchgesner (8, 9) , Guillaume Bouguen (10, 11, 12) , Denis Franchimont (13) , Guillaume Savoye (14, 15, 16, 17) , Anthony Buisson (18) , Edouard Louis (19) , Stéphane Nancey (20) , Vered Abitbol (21) , J.-M. Reimund (22) , Olivier Dewit (23) , Lucine Vuitton (24) , Nicolas Matthieu (25) , Laurent Peyrin-Biroulet (26, 27) , Cyrielle Gilletta (28) , Matthieu Allez (29) , Stephanie Viennot (30) , Caroline Trang-Poisson (31, 32) , Nina Dib (33) , Hedia Brixi (34) , Médina Boualit (35) , Laurianne Plastaras (36) , Lucile Boivineau (37) , Mathurin Fumery (38, 3, 39) , Ludovic Caillo (40) , David Laharie (41) , Aurelien Amiot (1) , Harry Sokol (42)

1 EC2M3 - Early detection of Colon Cancer using Molecular Markers and Microbiota (EA 7375)
2 CHRU Lille - Centre Hospitalier Régional Universitaire [CHU Lille]
3 INFINITE (Ex-Liric) - Institute for Translational Research in Inflammation - U 1286
4 Service de Gastroentérologie [Hôpital Beaujon]
5 Hôpital Nord [CHU - APHM]
6 CHU - Hôpital Pasteur [Nice]
7 CHU ST-E - Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne]
8 CHU Saint-Antoine [AP-HP]
9 LBM UMR 7203 - Laboratoire des biomolécules
10 CIC - Centre d'Investigation Clinique [Rennes]
11 NuMeCan - Nutrition, Métabolismes et Cancer
12 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou]
13 ULB - Hôpital Erasme [Bruxelles]
14 CHU Rouen
15 ADEN - Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau
16 UNIROUEN UFR Santé - UNIROUEN - UFR Santé
17 IRIB - Institute for Research and Innovation in Biomedicine
18 CHU Estaing [Clermont-Ferrand]
19 CHU-Liège - Centre Hospitalier Universitaire de Liège
20 APY - Autophagie infection et immunité - Autophagy Infection Immunity
21 Hôpital Cochin [AP-HP]
22 Voies de Signalisation du Développement et du Stress Cellulaire dans les Cancers Digestifs et Urologiques
23 UCL - Université Catholique de Louvain = Catholic University of Louvain
24 CHRU Besançon - Centre Hospitalier Régional Universitaire de Besançon
25 Département d'hépato-gastroentérologie
26 NGERE - Nutrition-Génétique et Exposition aux Risques Environnementaux
27 Service d'Hépato-gastro-entérologie [CHRU Nancy]
28 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
29 AP-HP - Hopital Saint-Louis [AP-HP]
30 CHU Caen
31 CHU Nantes - Centre Hospitalier Universitaire de Nantes
32 Institut des Maladies de l'Appareil Digestif
33 CHU Angers - Centre Hospitalier Universitaire d'Angers
34 Hôpital universitaire Robert Debré [Reims]
35 Centre hospitalier [Valenciennes, Nord]
36 Hôpital pasteur [Colmar]
37 Département d'Hépato-Gastroentérologie et de Transplantation Hépatique [CHU Saint-Eloi]
38 CHU Amiens-Picardie
39 PERITOX - Périnatalité et Risques Toxiques - UMR INERIS_I 1
40 CHU Nîmes - Centre Hospitalier Universitaire de Nîmes
41 CIC Bordeaux
42 CRSA - Centre de Recherche Saint-Antoine

Background and aim - The inflammatory bowel disease [IBD]-disk is a 10-item self-questionnaire that is used to assess IBD-related disability. The aim of the present study was to evaluate this tool in the assessment of IBD daily-life burden. Methods - A 1-week cross-sectional study was conducted in 42 centres affiliated in France and Belgium. Patients were asked to complete the IBD-disk [best score: 0, worst score: 100] and a visual analogue scale [VAS] of IBD daily-life burden [best score: 0, worst score: 10]. Analyses included internal consistency, correlation analysis, and diagnostic performance assessment. Results - Among the 2011 IBD outpatients who responded to the survey [67.8% of the patients had Crohn's disease], 49.9% were in clinical remission. The IBD-disk completion rate was 73.8%. The final analysis was conducted in this population [n = 1455 patients]. The mean IBD-disk score and IBD daily-life burden VAS were 39.0 ± 23.2 and 5.2 ± 2.9, respectively. The IBD-disk score was well correlated with the IBD daily-life burden VAS [r = 0.67; p <0.001]. At an optimal IBD-disk cut-off of 40, the area under the receiver operating characteristic curve [AUROC] for high IBD daily-life burden [VAS >5] was 0.81 (95% confidence interval [CI]: 0.79-0.83; p <0.001). Conclusions - In a large cohort of patients, the IBD-disk score was well correlated with IBD daily-life burden, and it could be used in clinical practice.

Mots clés: Crohn’s disease; disability; inflammatory bowel disease; patient-reported outcome; ulcerative colitis

Domaines: Sciences du Vivant [q-bio]

Sara Tadbiri, Maria Nachury, Yoram Bouhnik, Mélanie Serrero, Xavier Hebuterne, et al.. The IBD-disk is a reliable tool to assess the daily-life burden of patients with inflammatory bowel disease. Journal of Crohn's and Colitis, 2021, 15 (5), pp.766-773. ⟨10.1093/ecco-jcc/jjaa244⟩. ⟨hal-03038348⟩