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Article Dans Une Revue Science Advances Année : 2021

Pinching the cortex of live cells reveals thickness instabilities caused by myosin II motors

Résumé

The cell cortex is a contractile actin meshwork, which determines cell shape and is essential for cell mechanics, migration, and division. Because its thickness is below optical resolution, there is a tendency to consider the cortex as a thin uniform two-dimensional layer. Using two mutually attracted magnetic beads, one inside the cell and the other in the extracellular medium, we pinch the cortex of dendritic cells and provide an accurate and timeresolved measure of its thickness. Our observations draw a new picture of the cell cortex as a highly dynamic layer, harboring large fluctuations in its third dimension because of actomyosin contractility. We propose that the cortex dynamics might be responsible for the fast shape-changing capacity of highly contractile cells that use amoeboid-like migration.
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hal-03395597 , version 1 (22-10-2021)

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  • HAL Id : hal-03395597 , version 1

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Valentin Laplaud, Nicolas Levernier, Judith Pineau, Mabel San, Lucie Barbier, et al.. Pinching the cortex of live cells reveals thickness instabilities caused by myosin II motors. Science Advances , 2021. ⟨hal-03395597⟩
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