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Biotransformation of guttiferones, Symphonia globulifera metabolites, by Bipolaris cactivora , an endophytic fungus isolated from its leaves

Abstract : The search for active microorganisms for the biotransformation of guttiferone A (1) and C (6) has been successfully undertaken from a collection of endophytic fungi of Symphonia globulifera. Of the twenty-five isolates obtained from the leaves, three are active and have been identified as Bipolaris cactivora. The products obtained are the result of xanthone cyclisation with the formation of two regioisomers among four possible and corresponding to 1,16-oxy-guttiferone and 3,16-oxy-guttiferone. The biotransformation conditions were studied. Interestingly, both oxy-guttiferones A are present in the plant, and the ratio of 3,16-oxy-guttiferone to 1,16-oxy-guttiferone is 4 : 1, very close to that observed by biotransformation (3.8 : 1). These results are consistent with the involvement of endophytes in their formation pathway from guttiferone A, in planta. Finally, biotransformation made it possible to obtain and describe for the first time oxy-guttiferones C.
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https://hal.archives-ouvertes.fr/hal-03262416
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Submitted on : Friday, November 26, 2021 - 5:15:03 PM
Last modification on : Saturday, June 25, 2022 - 9:11:16 AM
Long-term archiving on: : Sunday, February 27, 2022 - 8:01:21 PM

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Pauline Menelle, Jérôme Quintin, Kevin Cottet, yann Fromentin, Joëlle Dupont, et al.. Biotransformation of guttiferones, Symphonia globulifera metabolites, by Bipolaris cactivora , an endophytic fungus isolated from its leaves. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2021, 19 (6), pp.1378-1385. ⟨10.1039/d0ob02443k⟩. ⟨hal-03262416⟩

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