Chondrosarcoma Resistance to Radiation Therapy: Origins and Potential Therapeutic Solutions

Antoine Gilbert (1) , Mihaela Tudor (2, 3) , Juliette Montanari (1) , Kevin Commenchail (1) , Diana Iulia Savu (2) , Paul Lesueur (4, 5) , François Chevalier (1)

1 ARIA - Accueil et Recherche en Radiobiologie des Ions Accélérés
2 NIPNE - Horia Hulubei National Institute of Physics and Nuclear Engineering
3 UniBuc - University of Bucharest
4 UNICANCER/CRLC - Centre Régional de Lutte contre le Cancer François Baclesse [Caen]
5 ISTCT - Imagerie et Stratégies Thérapeutiques pour les Cancers et Tissus cérébraux

Chondrosarcoma is a malignant cartilaginous tumor that is particularly chemoresistant and radioresistant to X-rays. The first line of treatment is surgery, though this is almost impossible in some specific locations. Such resistances can be explained by the particular composition of the tumor, which develops within a dense cartilaginous matrix, producing a resistant area where the oxygen tension is very low. This microenvironment forces the cells to adapt and dedifferentiate into cancer stem cells, which are described to be more resistant to conventional treatments. One of the main avenues considered to treat this type of tumor is hadrontherapy, in particular for its ballistic properties but also its greater biological effectiveness against tumor cells. In this review, we describe the different forms of chondrosarcoma resistance and how hadrontherapy, combined with other treatments involving targeted inhibitors, could help to better treat high-grade chondrosarcoma.

Mots clés: chondrosarcoma; radiation resistance; hadrontherapy; carbon ions therapy; hypoxia; cancer stem cells

Domaines: Cancer

Antoine Gilbert, Mihaela Tudor, Juliette Montanari, Kevin Commenchail, Diana Iulia Savu, et al.. Chondrosarcoma Resistance to Radiation Therapy: Origins and Potential Therapeutic Solutions. Cancers, 2023, 15 (7), pp.1962. ⟨10.3390/cancers15071962⟩. ⟨hal-04058836⟩