Cytokine response following perturbation of the cervicovaginal milieu during HPV genital infection

Christian Selinger (1, 2) , Massilva Rahmoun (1, 2) , Carmen Lia Murall (1, 2) , Claire Bernat (1, 2, 3) , Vanina Boué (1, 2) , Marine Bonneau (2) , Christelle Graf (2) , Sophie Grasset (1, 2) , Soraya Groc (1, 2) , Jacques Reynes (2, 4) , Christophe Hirtz (5, 2) , Nathalie Jacobs (6) , Samuel Alizon (1, 2, 7)

1 MIVEGEC - Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle
2 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
3 IGF - Institut de Génomique Fonctionnelle
4 TransVIHMI - Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques et émergentes
5 Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB)
6 Université de Liège
7 CIRB - Centre interdisciplinaire de recherche en biologie

Human papillomaviruses (HPVs) are oncogenic viruses causing most cervical cancers. Highly prevalent in young, sexually active women, only a minority of HPV infections persist. To better characterize the immuno-modulatory impact of early HPV infections, we measured changes in a panel of 20 cytokines in cervicovaginal samples collected from young women who were tested for HPV and self-reported for genital inflammation and infection symptoms. Multi-factor statistical analyses revealed that increased IL-1Alpha and IL-12/IL-23p40 concentrations were associated with HPV infection, and that macrophage inflammatory proteins were associated in particular with high-risk HPV infections.

Mots clés: Human Papillomavirus; Cytokines; Natural history; Mucosal immunity

Domaines: Maladies infectieuses; Immunité adaptative; Gynécologie et obstétrique

Christian Selinger, Massilva Rahmoun, Carmen Lia Murall, Claire Bernat, Vanina Boué, et al.. Cytokine response following perturbation of the cervicovaginal milieu during HPV genital infection. Immunologic Research, 2021, 69 (3), pp.255-263. ⟨10.1007/s12026-021-09196-2⟩. ⟨hal-03354891⟩